When supplementing with hormones don't solve the problem

The majority of imbalanced or low sex hormones is caused by a regulatory dysfunction, collapse of norepinephrine.  Norepinephrine is a neurotransmitter found in the dopamine pathway of the brain.  When we are stuck in a chronic stress response we initially pump out increased amounts of glucocorticoids, namely cortisol.  Glucocorticoid excess starts to deplete dopamine in the brain.  Dopamine is needed to produce norepinephrine.  We can see this depletion when we run an Organic Acid test and see the metabolites homovanillate and vanilimandelate excreted in the urine.  This tells us if these neurotransmitters are turning over at a rapid pass or are depleted.

By utilizing Amino Acid Therapy we can begin to replete this pathway.  So the first step in proper management of hormone issues is to restore regulatory function, not administering hormones on top of a collapsed system regulation.  The anti-aging community embraces hormone replacement while giving no thought to the underlying collapsed norepinephrine in the dopamine pathway that exists for most people.  This is why you see people on long term administration of progesterone for woman and testosterone for men.  

Why does BHRT work for a while but then the person starts to see a return of symptoms, or the dose has to be increased or for some never works at all?

Really the only way of getting central and peripheral norepinephrine levels consistently high enough is to use Amino Acid Therapy and proper nutrition to fuel the body appropriately to relieve the stress caused by inflammation from overloading on carbs.  Nutrition plays an enormous role on the stress response system causing depletion in neurotransmitters.   Amino Acid Therapy is very safe when properly used in balance with the co-factors and sulfur thiols and gets to the root cause of the problems.  Once the levels are brought back to normal along with proper nutrition and lifestyle changes you are done.  These protocols are not permanent but supplemental, when you are done, you're done.